An absorbent article with waist seals has been granted a patent. The seals are formed from folded stacks, discrete segments, or pleated material arranged to provide a resiliently compressible seal that can be located at one or more locations within the absorbent article, e.g., along a central portion of the rear waist region of a diaper. The seals may be constructed from relatively thin materials that (through folding, stacking, pleating, etc.) can provide a resiliently compressible seal that is thick enough and appropriately shaped to conform to the wearer's anatomy well enough to provide the desired sealing. At the same, time, the continuous web material used to form the seal is preferably thin enough to be economically delivered to the manufacturing line in roll form. The seals may be provided in the form of compressed seals that expand when one or more openings are formed in a sealed cavity containing compressed resilient material.